The Versatile Type VI Secretion System
نویسندگان
چکیده
منابع مشابه
Type VI secretion system
Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells.
متن کاملMarker for type VI secretion system effectors.
Bacteria use diverse mechanisms to kill, manipulate, and compete with other cells. The recently discovered type VI secretion system (T6SS) is widespread in bacterial pathogens and used to deliver virulence effector proteins into target cells. Using comparative proteomics, we identified two previously unidentified T6SS effectors that contained a conserved motif. Bioinformatic analyses revealed t...
متن کاملType VI secretion system: secretion by a contractile nanomachine
The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is initiated by formation of a membrane complex that binds a phage-like baseplate with a sharp spike, and this is followed by polymerization of a...
متن کاملThe type VI secretion toolkit.
Bacterial secretion systems are macromolecular complexes that release virulence factors into the medium or translocate them into the target host cell. These systems are widespread in bacteria allowing them to infect eukaryotic cells and survive or replicate within them. A new secretion system, the type VI secretion system (T6SS), was recently described and characterized in several pathogens. Ge...
متن کاملThe rise of the Type VI secretion system
Bacterial cells have developed multiple strategies to communicate with their surrounding environment. The intracellular compartment is separated from the milieu by a relatively impermeable cell envelope through which small molecules can passively diffuse, while larger macromolecules, such as proteins, can be actively transported. In Gram-negative bacteria, the cell envelope is a double membrane...
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ژورنال
عنوان ژورنال: Microbiology Spectrum
سال: 2016
ISSN: 2165-0497
DOI: 10.1128/microbiolspec.vmbf-0026-2015